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This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 668596

ChiLTERN Newsletter 11
June 2018

Welcome to ChiLTERN's quarterly newsletter, a publication sent to the whole Project network. This is aimed at keeping everyone updated with the progress of the Project. With over 20 collaborators across the United Kingdom, Belgium, Spain, Italy, Switzerland, Germany, Poland, France, Norway, Sweden, Ireland and the Czech Republic, our comprehensive research programme is connected to the single largest clinical trial ever to be undertaken amongst the paediatric liver cancer population. Ultimately, ChiLTERN will aim to cure more children with liver cancer, expose fewer children to toxic chemotherapy and ensure their surgery is both effective and safe.
Work Package 1 - Project Management
Meetings and events
It was great to see those not affected by the Italian air traffic control strikes and who managed to make the Collaborators’ Meeting on Tuesday 8th May 2018 at the stunning Società Medico Chirurgica in Bologna, Italy. Twenty nine beneficiary representatives attended the meeting to listen to work package updates and have the opportunity to discuss the practicalities of ChiLTERN.
Following the meeting, colleagues met at the Circolo Bononia for an enjoyable ‘working dinner’.
Feedback from the day was very positive with most colleagues finding the meeting informative and useful. They also felt that the face-to-face meetings provide a good opportunity to interact with other Project colleagues. Based on feedback received, the next meeting will be scheduled in a well-connected location with direct flights from most destinations. There will also be Wi-Fi access! The next ChiLTERN Collaborators’ meeting will take place in 2019 at a date and location to be confirmed.

Grazie mille go to CINECA for hosting the consortium over the two days in Italy.

On the morning of Wednesday 9th May, the External Advisory Board met to discuss Project progress, deadlines, patient and public involvement and communication activities. The Board also provided feedback on work package updates and agreed that the Project aims and objectives are still relevant.

The Internal Project Board meeting followed with agenda items including project management, communication, the PHITT trial, biology and pathology, CHIC, surgery and toxicity of chemotherapy as well as the PHITT online remote data entry system (eRDE). Eiso Hiyama, ssociate partner from the Japanese Children’s Cancer Group (JCCG) was present to inform the Board how the PHITT trial is progressing in Japan. Gregory Tiao from the Children’s Oncology Group (COG) reported by phone on how the PHITT trial is progressing in the USA.
The first contract amendment is still in consultation but making good progress. ChiLTERN is looking forward to extending the network and bringing new beneficiaries on board! All future contract amendments will be requested separately to avoid delays where possible.
Budget transfers and reallocation
Amendment needed?
From one beneficiary to another NO
From one budget to another NO
Reallocation of tasks shown in Annex 1 YES
Transfer between category of costs YES, if the category receiving the transfer was not included in the budget
Transfers within personnel costs NO
Transfers to costs of internally invoiced goods and services NO
New subcontracts YES
Please remember that all Project participants have signed the Consortium Agreement
“Each Party undertakes to take part in the efficient implementation of the Project, and to cooperate, perform and fulfil, promptly and on time, all of its obligations under the Grant Agreement and the Consortium Agreement as may be reasonably required from it.

Each Party undertakes to notify promptly, in accordance with the governance structure of the Project, any significant information, fact, problem or delay likely to affect the Project.”

If you are no longer able to meet your contractual obligations, please get in touch with Louise Woodall by email at
Work Package 2 - PHITT
We are also pleased to announce that Su Lee has now been appointed as Trial Coordinator and will be focusing on NCCs and European partners. 

The following sites are now opened:-

Royal Aberdeen Children's Hospital
Birmingham Children’s Hospital
Bristol Royal Hospital for Children
Addenbrooke's Hospital
Great North Children’s Hospital, Newcastle
Royal Belfast Hospital for Children
Royal Hospital for Sick Children, Edinburgh
Royal Hospital for Children Glasgow
Leeds General Infirmary
Royal Liverpool Hospital
Royal Manchester Children Hospital
Queen's Medical Centre, Nottingham
John Radcliffe Oxford
Royal Mardsen Hospital (RMH)
Sheffield Children's Hospital

Our Lady's Children's Hospital

Oslo University Hospital
Hospital Universitari Vall d'Hebron’ Barcelona
Hospital Universitario 12 de Octubre, Madrid
Hospital Universitaro De Cruces, Bilbao
Hospital Reina Sofia
For more information please see
Work Package 3
On 12th April, the online Site Initiation Visit of the PHITT trial was presented in Spain to 10 different hospitals. Dra M Elena Mateos and Antonio Luque, from Cordoba (NCC Spain) provided a brief status and gave an outline of the PHITT trial.  Dra Carolina Armengol and Dra Montse Domingo explained the sample collection process (type of samples, time points), the use of the kits and the shipment process. This presentation was repeated for the remaining sites in Spain on 5th June. 

On 8th May, the ChiLTERN Collaborators' meeting took place in Bologne. Dra Armengol presented a summary of WP3 work including the samples collected up to-date. During the meeting, she confirmed that samples have been collected from 12 out of 13 (92%) PHITT patients, however not all samples have been collected from all patients (the average of samples collected is 58% by patient). Carolina stressed the need to improve the snap-frozen tissue samples collected at diagnosis and surgery, but was really satisfied how the sample collection is working at the beginning of the trial.

Dra Armengol would like to thank to all people involved in the process of sample collection (surgeons, pathologists, oncologists, radiologists, nurses, researchers, administrative staff,…), and especially to the patients and their families.
The pictogram above shows the great work that UK and Spanish hospitals have done to collect biological samples in order to achieve ChiLTERN objectives. We would like to encourage all sites to reach 100% samples collection!
WP3 members and Dr Marie Annick Buendia from the External Advisory Board of the ChiLTERN project after the working dinner in Bologna
Work Package 4 - CHIC
Nothing to update.
Work Package 5 - Surgery
Nothing to update.
Work Package 6 - Toxicity of chemotherapy
Gareth Veal and the group have been working hard on the development and validation of assays which will be utilised for the cardiac biomarker studies associated with the PHiTT trial. Assays currently being investigated include those for Troponin I, myosin-binding protein C and NT-proBNP. An assay for the quantification of cisplatin in clinical samples to be collected as part of the PHITT trial has been developed and fully validated and the first pharmacokinetic samples will be analysed in June. We look forward to generating some interesting PK/PD data for this study over the coming months.
Work Package 7 - Results and Dissemination
Please remember to ......
ChiLTERN Website

The ChiLTERN website is regularly updated with news and information as it is received from beneficiaries. If you have any news or events relating to ChiLTERN or to the PHITT trial, do get in touch by email at so we can shout about our collaborative work.
ChiLTERN on Twitter

@chilterncollab has 57 followers, 20 more than reported in the last newsletter. We use Twitter to communicate the Project to multiple audiences in order to inform and engage with society. Please encourage others to follow us on Twitter to showcase how our work together is achieving more than otherwise possible.
If you have any news that you would like to be included in the next edition or you know anyone who would like to receive this newsletter, please get in touch with Norihan Mohd-Taib by email at  The next newsletter will be published in September 2018.

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