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This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 668596

ChiLTERN Newsletter 13

March 2019
We are pleased to bring you to ChiLTERN's 13th newsletter, a quarterly publication sent to our ever-growing Project network. This is aimed at keeping everyone updated with the progress of the Project. With over 23 collaborators across the United Kingdom, Belgium, Spain, Italy, Switzerland, Germany, Poland, France, Norway, Sweden, the Netherlands, Ireland and the Czech Republic, our comprehensive research programme is connected to the single largest clinical trial ever to be undertaken amongst the paediatric liver cancer population. Ultimately, ChiLTERN will aim to cure more children with liver cancer, expose fewer children to toxic chemotherapy and ensure their surgery is both effective and safe.
Work Package 1 - Project Management

The 2nd Periodic Report has been submitted to the European Commission

In order to receive payments, ChiLTERN beneficiaries are required to report on progress every reporting period. There are four reporting periods over the five year contract:
  • Reporting period 1 from month 1 (January 2016) to month 18 (June 2017)
  • Reporting period 2 from month 19 (July 2017) to month 36 (December 2018)
  • Reporting period 3 from month 37 (January 2019) to month 54 (June 2020)
  • Reporting period 4 from month 55 (July 2020) to month 60 (December 2020)
Over the last 60 days, colleagues have provided information and data to contribute to the technical report, providing an explanation of the work carried out, overview of progress and answers to complete the portal questionnaire. Most beneficiaries have also completed their individual financial statements to make up a financial report explaining the use of resources. 

Thank you to everyone who has contributed to getting the report complete and submitted on time. 
Save the date!!
The next ChiLTERN Collaborators' meeting will take place on Wednesday 3rd April 2019 in Munich, Germany. All ChiLTERN beneficiary representatives are invited to attend along with Associate Partners and members of the External Advisory Board. The Internal Project Board and External Advisory Board meetings will take place the following day on Thursday 4th April 2019. 
Work Package 2 - PHITT Trial
PHITT now has 50 sites open over 8 countries with 46 patients to date recruited from the UK, Spain, Norway, France, Belgium and Switzerland. Germany and the Netherlands should hopefully be open soon. 

Version 3.0 of the PHITT protocol is now approved in the UK and will be implemented in all sites. Guidance is now provided on the use of STS, among other improvements.

The PHITT database, developed by Cineca has been used by recruiting sites. There has been good feedback on its use and the team are already working on some improvements.

The next PHITT Clinical Trial Newsletter will be out at the end of March! 
Work Package 3 - Biology/Pathology
Work Package 3 in Japan - November 2018
WP3 colleagues Ronald de Krigjer (PMC), Christian Vokuhl (CAU), Torsten Pietsch (UKB), Roland Kappler (LMU) and Carolina Armengol (IGTP) attended the 50th Annual Congress of the International Society of Paediatric Oncology (SIOP) in Kyoto, Japan, from 16th to 19th November 2018, where two ChiLTERN posters where presented.
After the SIOP meeting, they all moved on to Hiroshima for the Childhood Liver Tumours Strategy Group (SIOPEL) meeting from 19th to 21st November and participated in several presentations. Carolina Armengol provided an update of WP3 and presented the biomarker study. Ronald de Krigjer gave a talk called “Pathology Review of European Liver Tumours”. “Exploratory study: The ChiLTERN exome sequencing project on high risk hepatoblastoma” was presented by Roland Kappler followed by Torsten Pietsch  who gave a talk on “Genomic Landscape of pediatric HCC”.

WP3 other news.....
In the framework of the ChiLTERN Patient-Derived Xenograft (PDX) program, the second tumour engraftment from a patient enrolled in the PHITT trial took place in November 2018. In this case, the tumour coming from Barcelona (Spain) was sent to IRP (Padova, Italy) for engraftment.

Recently, WP3 biology partners have been working on a bio-markers panel together with US PHITT collaborators. Once this is finally agreed, it will be used to test in all PHITT samples.

Work Package 4 - Validation of a clinical risk stratification for hepatoblastoma (CHIC)
There was a CHIC meeting in Kyoto, Japan in November 2018, which was attended by some of our ChiLTERN Work Package 4 colleagues.  
Work Package 5 - Surgery
2019 is expected to be an exciting year for WP5. Look out for updates in future ChiLTERN newsletters. 
Work Package 6 - Toxicity of Chemotherapy
As more patients are recruited on to the PHITT trial, activity in work package 6 is expected to increase. Watch this space for how Gareth and his team are getting on in future newsletters. 
Work Package 7 - Results and Dissemination
ChiLTERN website
The ChiLTERN website is regularly updated with news and information as it is received from beneficiaries. We need to inform interested groups that our research and innovation will impact on society and people's lives by keeping these pages up-to-date and appealing. If you have any news or events relating to ChiLTERN and PHITT, do get in touch by email at so we can shout about success!
ChiLTERN on Twitter

@chilterncollab has 72 followers! As ChiLTERN progresses, social networking will allow the Project to expand its audience globally as part of the communication and promotion activities within work package 7. Please encourage others to follow @chilterncollab to showcase how our work together is achieving more than otherwise possible.  
If you have any news that you would like to be included in the next edition or you know anyone who would like to receive this newsletter, please get in touch with Louise Woodall by email at by Tuesday 16th April 2019. 

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